BEST FIX: C:\windows\system32\config\systemprofile\desktop refers to a location that is unavailable –...

If you’re on Windows 10, you’ll encounter this error just like I did recently. This is the best fix I found so far. Note: If you managed to fix that missing “systemprofile\desktop” error, you’ll have a problem with missing pinned taskbar icons. To fix that blank paper icon on the taskbar, don’t use “the right click and pin to taskbar” method. - http://den-i.com/best-fix-cwindowssystem32configsystemprofiledesktop-refers-to-a-location-that-is-unavailable-appuals-com/